 UW-Madison MRSEC |
Semifluorinated Copolymers: A Novel Class of Materials for Drug Delivery |
Principal Investigators:
Sandro Mecozzi - smecozzi@pharmacy.wisc.edu
Glen Kwon - gskwon@pharmacy.wisc.edu
| Drs. Kwon and Mecozzi of the UW School of Pharmacy are working to synthesize and characterize the self-assembling, binding and release properties of a novel class of materials: monodisperse semifluorinated diblock and triblock copolymers. It is expected that these polymers will self-assemble in micellar aggregates upon dissolution in an aqueous phase. The presence of a perfluorinated segment in the polymer will induce the formation of an internal fluorous phase that will dramatically increase the stability of the micelles when compared to common non-fluorinated micelles. These properties make the proposed polymers ideal candidates for achieving stable nanoscopic vehicles, a long searched goal in the general field of drug targeting. |
